Tuesday, 31 May 2016

Why you should avoid (vitamin D) supplements



Here's why:-
  • Under-appreciation of the fact that vitamin D is a hormone with diverse and dose-dependent systemic effects, still not fully understood
  • Misleading  claims that vitamin D supplementation is “equivalent”  to vitamin D from sun exposure. While the two forms are chemically identical, levels of vitamin D3 synthesized from sun exposure are self-limiting due to feedback regulation.  What happens when we chronically exceed natural limits?
  • Inadequate attention to the possible effects of chronic vitamin D supplementation on homeostatic down-regulation of the VDR receptor. See this discussion bv Dr. David Agus of USC medical school.
  • Inadequate study of the possible long term adverse effects of chronic vitamin D supplementation. Few studies look beyond 4 years. Hormone replacement therapy was in favor for 50 years before the risks came to light . Things don’t necessarily look any more promising when synthetic hormones are replaced bioidentical hormones.

Todd states there are several ways you can naturally activate autophagy in your body.  It turns out that all of them involve one form of hormesis or another:-
  • Calorie restriction and intermittent fasting.  In my post on Calorie restriction and hormesis,  I summarized some of the research on calorie restriction in humans, primates and other animals. including the role played by autophagy and other mechanisms.  This is also described in my talk onIntermittent Fasting for Health and Longevity.
  • Brief, strenuous exercise.  A 2012 paper in Nature by Levine et al. in mice found that “Exercise is even faster than starvation” at inducing autophagy… “If you just exercise the mice for 30 minutes on a treadmill, autophagosomes start to form. Thirty minutes of running induces autophagy 40 to 50 percent.”
  • Hormetic stress in general.   A wide range of short term, intense but sublethal stressors have been shown to activate autophagy via a common pathway.  Criollo et al.  showed that multiple stressors, including nutrient starvation and numerous chemicals, trigger the activation of the IKK (IκB kinase) complex, inducing the classical autophagy pathway involving p53 depletion, mTOR inhibition, AMPK and JNK1 activation, and release of the pro-autophagic protein Beclin-1.  How many of the other hormetic stressors we’ve discussed in this blog– such as cold showers–might effectively activate autophagy?

Friday, 26 December 2014

Caloric Restriction, Hormesis, and what they teach us about Evolution by Josh Mitteldorf

“If aging is driven by damage, then damage must accelerate aging. If hormesis induces damage and slows down aging, then aging is not driven by damage. So a straightforward explanation is that aging is not caused by accumulation of molecular damage.” –Mikhail Blagosklonny
http://goo.gl/jldZ7m

Thursday, 11 December 2014

Post on Hormesis - useful summary of the key issues by Josh Mittledorf
"Maybe the fact that overeating is bad for our longevity is so familiar to you that you no longer think it’s strange.  But believe me, it’s strange.  It’s strange that the harder you work your body the longer it lasts."
Particularly why science community ignores it still:-

  • Association with the problematic science of homeopathy.  In the early 20th Century, people who promoted homeopathic medicine were prominent supporters of the concepts of hormesis.
  • Polluters and chemical manufacturers seized on the idea to argue, opportunistically, that pollution is actually a boon to public health!  In fact, owners of nuclear power plants argue that leakage of radiation is not a problem as long as it is below a threshold dose*.
  • The true strangeness emphasized above.  Hormesis implies that the body is unable to be fully healthy if it has all the food it needs, and is deprived of poisons and stressors.
http://joshmitteldorf.scienceblog.com/2014/12/09/what-doesnt-kill-me-makes-me-stronger/

Saturday, 13 July 2013

Antifragile - by Nassim Nicholas Taleb

Excellent review of Nassim Nicholas Taleb' Antifragile at Getting Stronger

Key points, from a hormesis perspective - quoted from Getting Stronger :-

The Barbell Strategy.  One of the hallmarks of fragility is that the downside is much worse than the upside. Taleb realized this as an options trader and developed a bimodal investment strategy, using the image of a barbell as a metaphor for pursuing the extremes instead of the average.  Rather than “diversify” into areas of average risk, he advises putting the majority of assets into ultra-safe investments like cash, and a small amount–say 10%–into some investments that are riskier but have a disproportionately huge upside.  This is an “asymmetric” or lopsided strategy which protects on the downside and has the possibility of great gain on the upside.

How does the barbell strategy apply to health?  A great example is combining occasional, high intensity weight lifting or interval training, alternating with long stretches of rest, recovery and  ”doing nothing”.

Asymmetric Optionality.   Accepting the idea that we should use the majority of our assets to protect solidly against the downside, how do we decide to invest our money, time, or energies to maximize the upside?  Taleb’s answer is to create asymmetric options.  An option is not just any “investment” — it is something you can chose to act on, but have no obligation to act upon.  Taleb’s idea is to seek out or create options that have a strong upside, but very low cost or downside. He cites the example of the Greek philosopher Thales, who bought the rights to use idle olive oil presses for a very low fee.  When an unusually good olive harvest came, he reaped a fortune by renting out the oil presses to growers who had to come to him.  Look for asymmetric options in areas besides just investing.  For example, if you can secure a rent-controlled apartment, you are protected against rent increases, but if rental rates go down elsewhere, you are free to move.  In your contracts, insist on the option to cancel at will without cost. (Don’t sign up for long term phone contracts!).

See Getting Stronger

Saturday, 13 April 2013

Stoicism for Modern Stresses: 5 Lessons from Cato


1) Master the power of gestures.
We talk about our times as the age of information overload, but public figures in all ages have had to compete to be heard. Ancient Rome was saturated with political talk: popular lawyers like Cicero consistently drew huge crowds, and the Roman people could regularly hear all-day parades of political speeches in the Forum. How could someone break through all that noise?
Cato understood that actions are far easier to “hear” than words. So he perfected a style of politics-by-gesture. He went barefoot. He wore his toga commando (then, as now, not the fashionable thing to do). He walked alone without the usual entourage of aides. He slept in the trenches with his troops rather than relax in a tent; he marched alongside them rather than ride a horse. He surrounded himself with philosophers, not political advisors. Just a second’s glance at him told an onlooker everything he needed to know about Cato. Those gestures, more than any vote cast or speech given, made his reputation.
[TIM: Not unlike Gandhi's 1930 Salt March.]
Even his death at the end of Rome’s civil war was a statement against his enemies. One night, he retired to his room after dinner, and loudly called for a book—Plato’s dialogue Phaedo—and his sword. The Phaedo tells the story of the death of Socrates, a philosopher too principled to live, forced to drink poison by the political authorities. Cato wanted everyone to see the parallels. Then he gritted his teeth and disemboweled himself.
To this day, his gesture against tyranny speaks as loud as any book or speech on the subject.
2) Don’t compromise—ever.
The Stoics taught Cato that there were no shades of gray. There was no more-or-less good, no more-or-less bad. Whether you were a foot underwater or a fathom, you were still drowning. All virtues were one and the same virtue, all vices the same vice.
It is the kind of austere scheme that seems unreasonable to live by and almost entirely impossible for the flux of war and politics. But Cato made it work. He refused political compromise in every form, to the point that bribe-takers turned his name into an aphorism: “What do you expect of us? We can’t all be Catos.”
He demanded the same of his friends, his family, and his soldiers. He was infuriating to his enemies, and he could seem crazy to his allies. And yes, sometimes he took his adherence to principle down absurd, blind alleys. But he also built an impossible, almost inhuman standard that brought him unshakable authority. By default, he became Rome’s arbiter of right and wrong. When Cato spoke, people sat up straighter. When he was carted off to jail by Julius Caesar, the entire Senate joined him in sympathy, forcing Caesar to let Cato go.
Many in Cato’s day spent their fortunes and slaughtered armies in pursuit of that kind of authority. But it can’t be bought or fought for—it’s the charisma of character. His countrymen couldn’t all be Catos, but they could join whichever uncompromising side of the argument Cato was on.
3) Fear nothing.
On election day during a consequential race, Cato and his brother-in-law rose before dawn and set off for the polls. Both were on the record against the front-runners, men bearing grudges (and armies) against Cato.
They were ambushed. The torchbearer at the head of Cato’s party collapsed with a groan—stabbed to death. The light clattered to the pavement, and they were surrounded by shadows swinging swords. The assailants wounded each member of the party until all had fled but Cato and his brother-in-law. They held their ground, Cato gripping a wound that poured blood from his arm.
Their attackers were under orders to maim and frighten them, not to kill. The message sent, they fled through the streets. Cato and his brother-in-law were alone in the dark.
For Cato, the ambush was a reminder that if the front-runners were willing to perpetrate such crimes on the way to power, then one could only imagine what they would do once they arrived. It was all the more important that he stand in front of the Roman people, show off his wounds, and announce that he would stand for liberty as long as he had life in him. But his brother-in-law didn’t have the stomach for it. He apologized, left, and barricaded himself inside his home.
Cato, meanwhile, walked unguarded and alone to the polls.
Fear can only enter the mind with our consent, Cato had been taught. Choose not to be afraid, and fear simply vanishes. To the untrained observer, Cato’s physical courage was reckless. But in fact, it was among the most practiced aspects of Cato’s self-presentation. And it was this long meditation on the absurdity of fear—on its near-total insignificance but for our own belief in it—that enabled him to press forward where others gave in.
4) Use pain as a teacher.
Cato’s early Stoic training was as hard and uncompromising as he hoped to become. He walked around Rome in unusual clothing with the goal of getting people to laugh at him. He learned to subsist on a poor man’s rations. He went barefoot and bareheaded in heat and rain. He learned how to endure sickness in perfect silence.
What was the point? Pain and difficulty could build endurance and self-control. Cato was drilling himself to become indifferent to all things outside the magic circle of the conscience. He could be ridiculed, starving, poor, cold, hot, sick—and none of it would matter. As the Stoic philosopher Epictetus taught: “Where is the good? In the will. Where is the evil? In the will.”
All of Cato’s practice paid off. Seneca, the great imperial Stoic, relates a telling story. Visiting the public baths one day, Cato was shoved and struck. Once the fight was broken up, he simply refused to accept an apology from the offender: “I don’t even remember being hit.”
5) Don’t expect to control your legacy.
No one in Rome was more skilled at building a public image than Cato. And yet, for all of his best efforts, at the moment he died he became the property of other people. Cato spent two decades as a politician. He has spent two millennia as a political object.
Would Cato have approved of being publicly humiliated by Caesar after his death, paraded through Rome’s forum on a billboard depicting his grisly suicide? Would Cato have approved of being cast as the star of an Italian opera, complete with a romantic subplot? Would Cato have approved of being turned by the Founding Fathers into a symbol of American democracy?
Who knows? Our guess is that Cato, irascible as he was, wouldn’t have liked any of it—because, at each step, Cato has been made to serve values and cultures almost totally alien to him, ones he never could have imagined. But that’s what you get when you’re dead—if you’re lucky. That’s what all of this vaunted “immortal fame” looks like.
Cato’s Stoicism told him that everything we value—our wealth, our health, our success, our reputations, essentially everything not between our two ears—is ultimately beyond our control. Even if you live such an exemplary life that people are writing books about you 2,000 years after you’re in the ground, you probably wouldn’t be happy about it, and in any case, you’d still be dead. Which proves better than anything what the Stoics taught: the only reward for virtue is virtue.

What causes allergies and autoimmune disease?

Another excellent post at http://gettingstronger.org
In summary*:-
We should be sure to include ample amounts of prebiotic fiber in our diet

Fiber is required by the microbes we co-evolved with and rely upon intensely for our health.  The most important type of fiber is soluble fiber, particularly fructooligosaccharides and other non-starch polysaccharides that we can’t digest without the aid of bifidobacteria, lactobacilli and other beneficial bacteria.  To ensure a robust colonization of our gut by these microbes, we don’t need to “eat” them as probiotics and yogurts or transplant them through the rear end.  The most natural way to colonize your gut is to feed them by eating a high fiber diet, and to minimize the sugars that lead to intestinal “blooms” of deleterious bacteria like E. coli and C. difficult — which you might think of as “intestinal weeds”
images-4So: increase the volume of green, leafy cruciferous vegetables — such as kale, broccoli, brussel sprouts;  colored and bitter fruiting bodies like red and green peppers, herbs and spices like curcumin. Of course, fiber can be introduced from a great variety of vegetable sources beyond the cruciferous ones.  Avocados, artichokes strawberries, mushrooms, sweet potatoes…the list goes on.



*See http://gettingstronger.org/2013/03/what-causes-allergies-and-autoimmune-disease/#more-4190

Thursday, 11 April 2013

Feeling Hungry May Protect the Brain Against Alzheimer's Disease

The feeling of hunger itself may protect against Alzheimer's disease, according to study published today in the journal PLOS ONE. Interestingly, the results of this study in mice suggest that mild hunger pangs, and related hormonal pathways, may be as important to the much-discussed value of "caloric restriction" as actually eating less.
http://www.sciencedaily.com/releases/2013/04/130402182457.htm

Note: One of the first scientifically rigorous demonstrations of the benefits of hormesis was a 1934 study of calorie restriction (often abbreviated “CR”) in laboratory rats, conducted by Mary Crowell and Clive McCay at Cornell. (See 'Getting Stronger')

Sunday, 7 April 2013


Old toxicology beliefs are myths?

As an example of hormesis, in an interesting study, Brenda E Rodgers, of Texas Tech University in Lubbock gave mice a small dose of radiation by caging them in a Ukrainian forest around 1.5 km from where the Chernobyl nuclear accident occurred 18 years ago. It took about 10 to 45 days for the mice to get exposed to 0.1 Gy of radiation dose depending upon the location from the site of accident. Soon after the animals had been exposed to 0.1 Gy radiations, they were removed and bombarded with a high radiation lab dose of 1.5 Gy. Later blood tests showed that the mice that were kept in the site close to Chernobyl accident developed only half of chromosome breaks as opposed to controls who were straight bombarded with 1.5 Gy of dose...

Friday, 30 November 2012

Autogenics - the Yin of Hormesis

If Hormesis is the Yang, then Autogenics is the necessary Yin element - helpful in the recovery phase that allows the system to respond and adapt to the stressor.
Autogenics is one of the best methods to relax totally, in mind and body. With practise you can rapidly achieve a state of warmth and total relaxation, with a cool forehead and calm, detached mind as the objective.
I've been practising it for 25 years and  find it very helpful every morning, after a work-out.
You don't need a teacher - just find a good book or material on-line and then practise every day, ideally twice a day.

Wednesday, 14 September 2011

Hormesis, cell death and aging

Hormesis, cell death and aging

Isabelle Martins, Lorenzo Galluzzi and Guido Kroemer

Abstract

Frequently, low doses of toxins and other stressors not only are harmless but also activate an adaptive stress response that raise the resistance of the organism against high doses of the same agent. This phenomenon, which is known as "hormesis", is best represented by ischemic preconditioning, the situation in which short ischemic episodes protect the brain and the heart against prolonged shortage of oxygen and nutrients. Many molecules that cause cell death also elicit autophagy, a cytoprotective mechanism relying on the digestion of potentially harmful intracellular structures, notably mitochondria. When high doses of these agents are employed, cells undergo mitochondrial outer membrane permeabilization and die. In contrast, low doses of such cytotoxic agents can activate hormesis in several paradigms, and this may explain the lifespan-prolonging potential of autophagy inducers including resveratrol and caloric restriction.



Thursday, 3 March 2011

Paleo Diet

From http://www.paleonu.com/panu-weblog/2009/11/13/what-i-eat.html

Paleo diet:-

>> I don't count, weigh or measure and I only look up the contents of what I am eating for research purposes (curiosity or the blog).

I eat about 5 % of calories as carbohydrate right now. Partly that is because I seem to be somewhat starch intolerant and I see little point in adding things like potatoes and rice that I didn't eat much before. It is not because I am specifically following Kwasneiwski's optimal diet, it just works out that way. But many of my own premises lead the same direction as Kwasniewski, so that's just confirmation in my mind. I suspect anything from 0-30% carbs will work fine (for health) for most people. If you want to go beyond that to Kitavan levels with Yams or white rice, I doubt if that is as healthy, but that might be OK, too if you have extirpated the neolithic agents.

My staples are:

Grass fed beef and lamb, wild venison (whitetail deer), bison. I eat the hearts and livers, don't care for the kidneys. Codfish, wild salmon and trout from lake michigan, sashimi (maguro especially). Wild turkey (the bird not the liquor)

Eggs - pastured eggs averaging 4 a day - often garnished with green or red chili salsa and sour cream. Onions and mushrooms for accompaniment.

Whole cream - in coffee and straight up. Diesel #1.

Pastured butter - I use it to cook everything and add it to stews and chili. Diesel #2.

Bacon, smoked bacon and prosciutto ham maybe once a week. (Penn Jillette says bacon is the perfect food)

Occasional sardines in olive oil or water.

Cheeses - Gorgonzola, parmesan, cheddar, brie, etc.

Veggies mostly as condiments - Red, yellow and white onions, regular and portabella mushrooms, wild morels and chantarelles in season, asparagus, green beans, different varieties of chilis.

Our main fruit is tomatoes eaten whole or crushed in tomato sauce for stew or chili. Lots of avocado with breakfast. A handful of raspberries and occasionally blueberries topped with unsweetened whole whipped cream now and then. Add vanilla to the whipped cream.

"Nuts" - limited pecans, almonds and walnuts - not for health just for flavor.

Any day we eat factory meat or get a big dose of n-6 PUFAs in restaurant food (Mcdonald's burger without bun, barbecued store bought chicken, restaurant eggs fried in vegetable oil) we each take 1 teaspoon of Carlson's cod liver oil.

You know about the vitamin D - now 8000 units/day Carlson's drops in morning coffee.

Sunday, 5 December 2010

Hormesis: COLD

From Own Your Health - http://is.gd/ieMRi

Cold Showers: What’s the Evidence?

Some people have questioned the evidence behind hydrotherapy, especially the cold water treatments that are described in the book that Alexa Fleckenstein and I co-authored. German research supports the effects of cold water used on the skin as therapy. Unfortunately, the studies are in German, and they are small. (1) Because Pharma firms have no interest in inexpensive water cures, there probably won’t be big studies any time soon. Fact is, the German insurance system pays all or part of physician-prescribed treatments, including hydrotherapy and herbs. The importance and therapeutic potential of water, and especially cold water, are now simply taken for granted in Germany.(2) Here are some specific research studies supporting the health benefits of cold water treatments. Citations are listed at the end. (More cold water research details in Own Your Health (2003)

Boosting the immune system
A pilot study of immune effects from cold water therapy with a small number of breast cancer patients found significantly increased disease-fighting cell counts in every category examined, including neutrophils, lymphocytes, monocytes.(3)

Reducing the perception of pain
In a study in Japan, cooling by ice water was one of the “competitive stimuli” that reduced the perception of the pain of a laser beam on the skin. (4)

Improved circulation and function in the legs
A Swedish group administered three weeks of alternating cold and hot hydrotherapy to the legs of patients suffering from intermittent claudication (reduced blood flow) and found that improved systolic blood pressure in ankles and toes, reduced pain, and markedly better walking ability went beyond the results of standard treatment and persisted for at least a year after treatment.(5)

Swimming in the winter?
Ten healthy subjects who regularly swim during the winter were evaluated at Berlin’s Institute of Biochemistry at Humboldt University Medical School. Their blood and urine showed increased levels of anti-oxidants, which prevent cell damage, indicating their bodies’ increased tolerance to stress.(6)

(1)Summarized in Bühring, M., Naturheilkunde: Grundlagen, Anwendungen, Ziele (Natural Medicine: Basic Application and Goals), Munich, Verlag CH Beck, 1997.
(2)Haas, S.S., Hydrotherapy and more: Adapting Kneipp’s Natural Medicine to the U.S., Complementary Medicine for the Physician, 2000; 5(8):57,61-64.
(3)Kuehn, G., Sequential hydrotherapy improves the immune response of cancer patients. In: Mizrahi A, et al., (eds.) Potentiating Health and the Crisis of the Immune System: Integrative Approaches in the Prevention and Treatment of Modern Diseases. New York: Plenum, 1997.
(4)Kakigi R., et al. Pain relief by various kinds of interference stimulation applied to the peripheral skin in humans: pain-related brain potentials following CO2 laser stimulation. J peripher Nerv Syst 1996;1:189-198.
(5)Elmstahl, S. et al., Hydrotherapy of patients with intermittent cluadication: a novel approach to improve systolic ankle pressure and reduce symptoms. Int Angiol. 1995;14:389-394.
(6) Siems, W.G., et al., Uric acid and glutatione levels during short-term whole body cold exposure. Free Radic Biol Med. 1994;16:299-305.

Take a Cold Shower to Protect Against Colds and Flu This Winter

At first, it sounds crazy – can a cold shower really prevent colds and flu? But Dr. Alexa Fleckenstein, author of HEALTH 2 0: TAP INTO THE HEALING POWERS OF WATER TO FIGHT DISEASE, LOOK YOUNGER, AND FEEL YOUR BEST (McGraw-Hill 2007) says that a few seconds of cold water after your hot shower is scientifically proven to make you healthy – even if you’re in the cold water for less than 30 seconds a day.

Here are 6 ways that a short cold shower protects you from colds and flu:

1. A brief cold water shower will decrease your body’s “reaction time” to cold. The cold shower “teaches” the blood vessels in your skin to clamp down faster, so you are losing less warmth in draft or cold exposure. Especially, during the winter months while it’s cold outside, you’ll stay warmer, longer.

2. Gamma interferon and interleukin-4 are two important virus-fighting cytokines (immune system proteins) A new German study has shown that cold water exposure helps these two disease-fighters work better together, resulting in fewer viral colds.

3. A cold shower increases lymphocytes in the blood. Lymphocytes produce antibodies, which help fight germs.

4. A cold shower makes you breathe deeply. (A big gasp when the cold water hits the skin!) A deep breath opens closed or clogged alveoli (small air sacs in the lungs) which are then less prone to bronchitis and pneumonia. And deeper breathing means more oxygen for the whole body.

5. A cold shower increases blood flow in all organs, especially skin, heart and lungs. The pharynx/larynx ( organs of the throat) also benefit from the increased blood flow, and are better able to kill viruses.

6. And a cold shower lifts your mood. Depressed people get more colds – probably because depression lowers immunity. A brisk cold shower has been proven to lift the mood and lower stress, both of which jumpstart the immune response – which kills flu and cold germs!

Remember that cold water therapy works only if done regularly, and also needs a few weeks (about six) to work. Start with just your feet and hands in the cold water, and gradually work your way up to your whole body. It feels great!

IMPORTANT: Check with your doctor first. Contraindication include uncontrolled high blood pressure, and narrowing of the arteries.

Sunday, 14 November 2010

anti-agingfirewalls.com

The process of hormesis is thought to be mediated primarily via heat shock proteins (HSPs). This blog further explores how hormesis and heat shock proteins work, focusing primarily on the HSP70 superfamily of proteins... the complexity of the biomolecular processes involved... http://anti-agingfirewalls.com/2010/07/03/hsp70-to-the-rescue/

Getting Stronger

Great source of information on all things hormesis:
http://gettingstronger.org/hormesis/

Sunday, 21 March 2010

Does caloric restriction increase longevity?

Does caloric restriction increase longevity? Perhaps not - at least not in the way postulated in much of the media - unless you are a black 6 mouse...

Greg Critser (new book is Eternity Soup: Inside The Quest To End Aging,Harmony 2010):-

"Hormesis theory — the notion that caloric restriction (the only intervention that expands maximum lifespan in mammals — mice) works by putting the body in a kind of energy-saving hibernation state, is promising. But the pathway by which it seems to work—ratcheted down Insulin-like Growth Factor 1 (IGF-1), does not seem implicated in exceptional human longevity; in one recent study only 6 of 220 human centenarians had the mutated IGF -1 receptor. Also, human beings do very badly on low IGF 1. They get sick and die". See
http://www.scientificblogging.com

Friday, 27 November 2009

Hormesis and hormetins

From: http://hubpages.com/forum/topic/28456
Three main categories of hormetins can be:

-Physical hormetins - exercise (running, walking, weight lifting etc), temperature (hot sauna or cold baths), irradiation (sunlight, solar-treatments)

- Nutritional hormetins - food restriction (fasting, low calorie diet), spices (turmeric, clove), zinger, garlic, onion, and micronutrients (zinc). There are many many more nutritional hormetins yet to be identified, and synthetic hormetins yet to be synthesized.

- Mental hormetins - mental activity (reading, puzzle solving, chess), public speaking/performance, focussed attention (meditation), "falling" in love....

Accordingly, several dietary components, such as resveratrol, vitamins, and trace elements and minerals including iron, iodine, fluorine, selenium and copper and zinc are potential hormetins. Other potential hormetins are the so-called antioxidants such as alpha lipoic acid and coenzyme Q10 which, owing to their pro-oxidant activities in producing hydrogen peroxide, induce antioxidative defensive responses and ultimately may bring about beneficial effects. Another hormetin is a plant growth factor kinetin, which we have snown to have several anti-ageing effects in human skin cells, promotes the differentiation of keratinocytes by inducing stress response pathways.

Similarly, some components of certain medicinal plants used frequently in the traditional Chinese medicine and in the Indian Ayurvedic system of medicine are claimed to have anti-aging effects, which appear to be achieved through hormetic pathways. For example, celasterols and paeoniflorin present in some medicinal herbs have cytoprotective effects and induce HSP in human cells. Leaf extracts of Ashwagandha (Withania somnifera) also induce HSP synthesis in mammalian cells, which may be one of the reasons for its observed beneficial medicinal effects.

Curcumin: Another potential hormetin being tested for its biological effects is curcumin or diferuloylmethane. It is the active component in the commonly used food spice turmeric, and is derived from the roots of Curcuma longa. Curcumin is a co-inducer of HSP and has wide ranging biological effects depending on its dosage. We have undertaken studies to check the hormetic effects of curcumin on human keratinocytes and fibroblasts. We have previously reported that at lower doses (0.3 and 1 μM) curcumin stimulates proteasome activity, enhances HSP induction after HS, and stimulates sodium pump activity. We are now extending these studies to find out long term effects of curcumin treatment on cellular aging, differentiation and angiogenesis.

Rosmarinic acid: Another potential hormetin that we are testing is the rosmarinic acid (RA), which is a phenolic compound present in several medicinal plants such as those from the Labiatae family, for example Salvia officinalis (common sage) and Rosmarinus officinalis. We are now in the process of testing further the short term and the long terms effects of the hormetin RA on aging, wound healing, angiogenesis and differentiation of human cells. Our preliminary results show that human skin fibroblast cultures grown continuously in the presence of 20 μM RA for 50 days have a significant (33%) reduction in the number of cells showing senescence-specific β-galactosidase marker. Furthermore, there was 50% reduction in the proportion of enlarged cell population with high levels of green autofluorescence in RA-treated cultures, as measured by flow cytometery.


In conclusion, using human fibroblasts, keratinocytes, endothelial cells and bone marrow mesenchymal stem cells we have provided evidence in support of the view that hormesis can be applied successfully to aging research and intervention. This includes the effects of mild HS on various parameters of cellular aging and other functional characteristics, such as differentiation, wound healing and angiogenesis.

Saturday, 10 October 2009

Hormesis and Eating Less for Longer Life

From Life Style: -

"Reduce your calorie intake by eating according to your nutritional type, which is based on your unique biochemistry. This should reduce your food cravings. By giving your body the right amount of energy it needs, you will experience less hunger.

" Know the types of food and amount of nutrients required by your body. Then create the appropriate mix of proteins, carbohydrates, and fat. This approach to energy restriction puts more emphasis to the proportion of essential nutrients in the diet rather than the amount of calories. Having a well-proportioned mix of proteins, fats, and carbohydrates is the key to energy restriction. This explains why vegetable juicing is so effective in energy restriction. Vegetable juice is low in calorie, high in essential nutrients, and has no insulin-elevating ingredients."

Friday, 18 September 2009

Back Pain - one exercise brings relief

A remarkable treatment for back pain, slipped disc, lumbago, what you will. I have recovered from a severe prolapsed disc, after weeks of intense pain, in just a week of this treatment: just one simple, cost-free exercise, in a couple of minutes.
This may seem off-topic but it relates to hormesis, as we shall see – and is a major health benefit for all.
In summary, after thousands of hours of research, it turns out that amongst all of the physical characteristics measured, the endurance of the back-extensor (erector-spinae) muscles has the highest association with low-back pain. Strengthen the endurance of the back-extensors and you can help eliminate the risk of pain. Note this is about endurance, not strength per se: it is about the endurance of the muscles in the erect posture that we assume naturally, day-today.
So how can we increase the endurance?
This the exercise, simply lie prone (face down) on glute-ham machine, with your legs wedged under the leg support, hips on then pads, and hold a position so that your torso is unsupported and your whole body is in a straight line, parallel to the ground. It’s as if you were standing erect, but you’re body is actually at a 90 degree angle, parallel to the floor.
If you don’t have a glute/ham then use a table or other flat surface with the tops of your hips at the edge of the table – so that your legs are supported and your torso extends over the edge of the surface into empty space. The tension should be in your lower back muscles.
Keep your hands at your sides or crossed over your chest and have someone hold your feet down, and simply maintain your torso in a horizontal position, parallel with the ground and on the same level as the table top, for as long as possible.
Maintain this position for as long as you can, until you find your torso slowly lowering as your muscles tire. Men should aim for around 90 seconds, women for 60. Repeat daily, just once.
It works because you are stressing the back-extensor (erector-spinae) muscles directly, and so strengthening their endurance, but without imposing a commensurate level of downward pressure on your spine and the nerves and discs involved.
The relevance to hormesis is that the exercise represents a stressor, when performed to failure – with all the associated benefits.
You’ll also want to balance your abdominal strength with this exercise: on all fours, suck in your belly button and bring is as close to your spine as possible. Hold the position for as long as you can, and continue to breath of course.
See the excellent Sports Injury Bulletin here with details of the back exercise and source references in an article by Owen Anderson: see Sports Injury Bulletin.
Last word to author Owen Anderson: he explains as follows:-
“Well, there probably is a link between isometric endurance and endurance of the concentric and eccentric kinds. In addition, for much sporting activity the function of the spinal muscles is to keep the torso stable (think of long-distance runners, Michael Johnson sprinting, Tour de France cyclists, footballers surging toward the ball, basketball players getting ready to get off a shot, etc.). All of these actions are isometric in nature and certainly require the spinal muscles to ‘hold their positions’ for extended periods of time. An inability to maintain a safe position for the spine – as a result of spinal-muscle fatigue – may in fact predispose the back to small-scale injuries and the near-inevitability of low-back pain.”

Friday, 11 September 2009

Life's a sprint not a marathon

Top sports psychologist Jim Loehr says that to be a peak performer in any area, you have to find ways to renew your energy - physically, emotionally, mentally and spiritually.

Our body's energy systems work best when we turn them on - and then turn them off again.

The metaphor Loehr used was this: Life is not a marathon - it is a series of sprints.

This is the principle of oscillation - intense energy expenditure followed by gentle energy recovery. This is directly in accord with the principles of Hormesis.

This appeared in the Daily Mail, by Paul-McKenna:-

Once I understood the importance of incorporating recovery time into my schedule, I began to spend more of my time just relaxing.

On holiday, I would lie on the beach and feel the warmth of the sun, imagining each muscle relaxing from the top of my head all the way down to the tips of my toes.

Then, when I had returned home, I would imagine myself sunbathing on that beach.

As the nervous system does not differentiate between a real and a vividly imagined event, each time I took myself through that experience, my nervous system felt as though I was still on holiday.

Read more: Daily Mail

A Hormesis Routine

Beneficial effects are found with a varied routine over a 7-day cycle such as:-

- Big 5 weight routine, each set to failure (an important Hormesis principle)
- Sauna
- Tabata training on a cross-trainer
- cold bath/ shower
- 1 hour fast walk
- GXP training - see link
- DAY OFF
Also Daily Meditation or Autogenic Training