Does caloric restriction increase longevity? Perhaps not - at least not in the way postulated in much of the media - unless you are a black 6 mouse...
Greg Critser (new book is Eternity Soup: Inside The Quest To End Aging,Harmony 2010):-
"Hormesis theory — the notion that caloric restriction (the only intervention that expands maximum lifespan in mammals — mice) works by putting the body in a kind of energy-saving hibernation state, is promising. But the pathway by which it seems to work—ratcheted down Insulin-like Growth Factor 1 (IGF-1), does not seem implicated in exceptional human longevity; in one recent study only 6 of 220 human centenarians had the mutated IGF -1 receptor. Also, human beings do very badly on low IGF 1. They get sick and die". See
http://www.scientificblogging.com
Sunday 21 March 2010
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